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Date : 2001-05-31
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Mitochondria in the biology pathogenesis and treatment ~ Lastly mitochondria‐mediated apoptosis is essential in the pathogenesis of viral hepatitis however no optimal drug has been identified to prevent or treat liver injury In this respect mitochondria‐targeted antioxidants or caspase inhibitors look promising but require further investigation
Mitochondria in Pathogenesis John J Lemasters Springer ~ Mitochondria are organelles in each cell outside the nucleus and are the energy source of all cells As such they are crucial to the healthy functioning of cells Recent research has shown that mitochondrial dysfunction underlies a broad spectrum of disease from maternally inherited genetic
Mitochondria in the biology pathogenesis and treatment ~ Lastly mitochondria‐mediated apoptosis is essential in the pathogenesis of viral hepatitis however no optimal drug has been identified to prevent or treat liver injury In this respect mitochondria‐targeted antioxidants or caspase inhibitors look promising but require further investigation
Pathogenesis and treatment of mitochondrial myopathies ~ The functional significance of the homoplasmic changes associated with mitochondrial haplogroups has been confirmed Among the mendelian disorders a new form of “indirect hit” has been described in which the ultimate pathogenesis is toxic damage to the respiratory chain
Mitochondria and the pathogenesis of ALS Brain Oxford ~ Mitochondrial calcium uptake is required for glutamate excitotoxicity and there is a correlation between increases in mitochondrial calcium and increases in free radical generation which are linked with cell death Stout et al 1998 The mitochondrial permeability transition pore may be crucial in both necrotic and apoptotic cell death
Mitochondria and Fungal Pathogenesis Drug Tolerance ~ MITOCHONDRIA AND VIRULENCE OF HUMAN FUNGAL PATHOGENS In addition to being required for antifungal drug tolerance mitochondria have also been associated with the ability of fungal pathogens to cause disease
Mitochondria in the pathogenesis of diabetes a proteomic view ~ Mitochondria in the pathogenesis of diabetes a proteomic view Key Laboratory of Protein and Peptide Pharmaceuticals and Laboratory of Proteomics Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China
The Role of Mitochondria in the Pathogenesis of Type 2 ~ Given the complex and dynamic structure of mitochondria and the diversity and physiological importance of their multiple functions assessing the role of mitochondria in human pathology requires a comprehensive characterization not only of mitochondrial structure and abundance but also of the pathways that compensate for suboptimal mitochondrial capacity and functional output—which may then modify disease severity and progression
Dysregulated Interorganellar Crosstalk of Mitochondria in ~ Dysregulated Interorganellar Crosstalk of Mitochondria in the Pathogenesis of Parkinson’s Disease View FullText Download PDF The pathogenesis of Parkinson’s disease PD the second most common neurodegenerative disorder is complex and involves the impairment of crucial intracellular physiological processes
Mitochondrial Contribution to Parkinsons Disease Pathogenesis ~ Thus quality control of mitochondria may play an important role in PD pathogenesis if the essential clearance of defective mitochondria is impaired and damaged mitochondria accumulate utilising substrate and generating excess superoxide radicals
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